Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Houston, Texas 77030


Purpose:

This phase I trial is studying the side effects and best dose of rebeccamycin analog in treating patients with relapsed or refractory acute myeloid leukemia, myelodysplastic syndrome, acute lymphoblastic leukemia, or chronic myelogenous leukemia in blast phase. Drugs used in chemotherapy, such as rebeccamycin analog, work in different ways to stop cancer cells from dividing so they stop growing or die


Study summary:

OBJECTIVES: I. Determine the maximum tolerated dose and dose-limiting toxicity of rebeccamycin analogue (XL119) in patients with relapsed or refractory acute myeloid leukemia, myelodysplastic syndromes, acute lymphoblastic leukemia, or chronic myelogenous leukemia in blastic phase. OUTLINE: This is a dose-escalation study. Patients receive rebeccamycin analogue (XL119) IV over 1 hour on days 1-5. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients achieving a complete response (CR) receive 1 additional course beyond CR. Patients achieving a partial response (PR) or hematologic improvement (HI) receive 2 additional courses beyond PR or HI. Cohorts of 3-6 patients receive escalating doses of XL119 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.


Criteria:

Inclusion Criteria: - Diagnosis of 1 of the following: - Acute myeloid leukemia - Myelodysplastic syndromes, including 1 of the following: - Refractory anemia with excess blasts (RAEB) - RAEB in transformation - Chronic myelomonocytic leukemia in transformation with ≥ 10% peripheral blood or bone marrow blasts - Acute lymphoblastic leukemia - Chronic myelogenous leukemia in blastic phase - Relapsed or refractory disease, defined as 1 of the following: - Failed to achieve a complete response (CR) to a standard induction regimen - Relapsed after achieving a CR - Failed last cytotoxic regimen before study entry - No alternate, potentially curative option available - No known CNS disease - Performance status - ECOG 0-2 - SGOT and SGPT normal - Bilirubin normal - Creatinine normal - No symptomatic congestive heart failure - No unstable angina pectoris - No cardiac arrhythmia - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - HIV-positive patients with normal CD4 count and without AIDS-defining disease allowed - No history of allergic reaction attributed to compounds of similar chemical or biologic composition to rebeccamycin analogue (XL119) - No concurrent uncontrolled illness - No active or ongoing infection - No psychiatric illness or social situation that would preclude study compliance - No prior allogeneic stem cell transplantation - No concurrent prophylactic hematopoietic colony-stimulating factors (CSF) - No epoetin alfa or hematopoietic CSF during course 1 of study therapy - More than 7 days since prior cytotoxic chemotherapy except for hydroxyurea - More than 7 days since prior radiotherapy - Recovered from all prior therapy - No concurrent combination antiretroviral therapy for HIV-positive patients - No other concurrent anticancer agents or therapies - No other concurrent antileukemic agents or therapies - No other concurrent investigational agents or therapies - No other concurrent cytotoxic agents


NCT ID:

NCT00087204


Primary Contact:

Principal Investigator
Francis Giles
M.D. Anderson Cancer Center


Backup Contact:

N/A


Location Contact:

Houston, Texas 77030
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.