Salt Lake City,
The purpose of this study is to examine the way the dietary supplements glucosamine and
chondroitin are absorbed and distributed throughout the body.
Osteoarthritis is the most common musculoskeletal disease in the world. While predisposing
conditions have been identified, the actual cause of osteoarthritis remains unknown.
Traditional treatments, most often anti-inflammatory drugs and pain relievers, produce
variable results and may cause significant toxicity. The use of complementary and
alternative therapies in the treatment of osteoarthritis has become more common, and
particular interest has focused on glucosamine and chondroitin treatments. This study will
examine the pharmacokinetics of glucosamine and chondroitin.
This study consists of two phases. In Phase I, participants will have two study visits,
during which multiple blood samples will be taken to determine levels of glucosamine and
chondroitin found naturally in the body. During Phase II, participants will be randomly
assigned to receive glucosamine, chondroitin, or a combination of the two for 3 months.
Blood samples will be taken at each of the three Phase II study visits to examine the
pharmacokinetics of glucosamaine and chondroitin.
- Able to walk
- Allergy to glucosamine, chondroitin, or shellfish
- Liver or kidney disease
- Diabetes mellitus
- Concurrent use of other complementary or alternative therapies