The purpose of study is to determine whether cranberry juice interacts with antibiotics used
to treat urinary tract infections (UTIs).
Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent
urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may
affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study
will determine whether concurrent cranberry juice administration lowers the urinary
concentrations of two commonly used antibiotics, amoxicillin and cefaclor.
This study will involve children being treated for UTIs and adults without UTIs. All of the
children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days
of antibiotic treatment, the children will be assigned to receive either cranberry juice for
2 days or no additional treatment. Urine samples will be collected from all child
participants before and after the administration of cranberry juice to examine the excretion
of the antibiotics.
Adult participants will receive two different doses of amoxicillin, with or without
cranberry juice. Blood and urine samples will be collected to evaluate the effect of
cranberry juice on the absorption and elimination of amoxicillin.
Inclusion Criteria for Children:
- Urinary tract infection (UTI) treated with cefaclor or amoxicillin
Inclusion Criteria for Adults:
- No UTI
- Allergies to antibiotics
- Use of medications other than oral contraceptives
- Pregnancy or breast-feeding