The purpose of this study is to demonstrate that in patients undergoing coronary artery
bypass grafting (CABG) or CABG-Valve, or Isolated Cardiac Valve surgery on CPB (cardiac
surgery), Angiomax is a safe and effective alternative anticoagulant to heparin with
- Provide written informed consent before initiation of any study related procedures.
- Be at least 18 years of age.
- Be scheduled for CABG, CABG and single valve surgery, or isolated single valve
surgery on CPB. Patients undergoing repeat (redo) CABG are also considered eligible
for this study.
- Confirmed pregnancy at time of randomization via IVRS (if woman of child-bearing
potential) (Urine or serum pregnancy test)
- Cerebrovascular accident within 6 months, or any cerebrovascular accident with a
residual neurological deficit.
- Intracranial neoplasm, arteriovenous malformation or aneurysm.
- Dependency on renal dialysis or creatinine clearance <30 mL/min.
- Ongoing treatment with warfarin (or other oral anticoagulant) at the time of
Patients previously treated with warfarin may be enrolled if warfarin therapy can be
safely discontinued and baseline INR is < 1.3 times control in the absence of heparin
- Known allergy to Angiomax or hirudin-derived drugs, or known sensitivity to any
component of the product.
- Patients receiving clopidogrel (Plavix®) within the previous 5 days of randomization
- Patients receiving a glycoprotein IIb/IIIa inhibitor within the previous 48 hours if
abciximab (ReoPro®) or 24 hours if eptifibatide (Integrilin®) or tirofiban
(Aggrastat®) of randomization.
- Patients receiving lepirudin (Refludan®) or argatroban within the previous 24 hours
prior to randomization.
- Patients receiving LMWH or thrombolytics within the previous 12 hours or
unfractionated heparin within 30 minutes of randomization.
- Participation in other clinical research studies involving the evaluation of other
investigational drugs or devices within 30 days of randomization.
- Refusal to undergo blood transfusion should it become necessary.
- Any other disease or condition, which, in the judgment of the Investigator, would
place a patient at undue risk by being enrolled in the trial, or cause inability to
comply with the trial.
- Planned surgical procedure in which proximal anastomoses will precede distal
anastomoses of the bypass grafts.
- Planned (>1) double (or greater) valve repair-replacement (e.g.: AVR-MVR) surgery.