This protocol will test whether Type 1 diabetes (T1DM) can be reversed in patients with
stable renal allografts by islet transplantation.
We will test whether pancreatic islets isolated from cadaveric human donor pancreata can be
transplanted into the portal vein of patients with T1DM who have stable renal allografts to
achieve insulin independence for the recipient. The protocol will employ a defined islet
isolation procedure, percutaneous islet infusion into the recipient's portal vein via an
intra-portal catheter, tight glycemic control during the peri-transplant period, and an
immunosuppressive protocol that avoids glucocorticoids.
- Patients with type 1 diabetes with stable renal allografts