Expired Study
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Worcester, Massachusetts 01605


Purpose:

This observational study will evaluate data from infants born to HIV infected mothers in order to better characterize disease progression in early HIV infection.


Study summary:

The role of HIV-specific cytotoxic T-lymphocytes (CTL) in controlling viremia and protecting against disease progression following vertical infection may be dependent upon CTL functional responses as well as on the timing of detection, magnitude, and breadth of the responses. Novel and sensitive assay systems (MHC-peptide tetramers, ELISPOT assays, intracellular cytokine assays) have enhanced the detection and characterization of virus-specific CTL responses in the peripheral blood. This study will use these novel methods to examine the timing of detection, magnitude, specificity, and in vitro functional properties of HIV-specific CTL in infants; to evaluate the effects of potent combination antiretroviral therapy on HIV-specific CTL in infants; and to evaluate the immunogenicity of recombinant pox-based vaccines in HIV infected infants with prolonged viral suppression following early potent combination antiretroviral therapy. Blood samples from infants born to HIV infected women will be obtained from infants enrolled in other HIV trials. Generally, samples will be obtained at birth, Week 1, and Months 1, 2, 4, 6, 9, and 12.


Criteria:

Inclusion Criteria: - Infants and children born to HIV infected women


NCT ID:

NCT00073229


Primary Contact:

Principal Investigator
Katherine Luzuriaga, MD
University of Massachusetts, Worcester


Backup Contact:

N/A


Location Contact:

Worcester, Massachusetts 01605
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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