The purpose of this research study is to determine the effectiveness of 2 target doses of
R228060 in comparison with placebo during 6 weeks of treatment in moderately to severely
depressed adult subjects with major depressive disorder.
Approximately 488 subjects will be involved in the study.
- Generally healthy adults on the basis of a physical examination, medical history, ECG
and laboratory work-up.
- Subject needs to meet criteria for diagnosis of moderate or severe major depression
as defined by the protocol.
- The subject also needs to be an outpatient to participate in this study.