Expired Study
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Baltimore, Maryland 21205


Purpose:

The purpose of this study is to determine whether probiotics, bacteria that may improve liver health, can effectively treat a chronic condition in diabetics that increases fat in the liver.


Study summary:

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States and is also common in diabetics; unfortunately, research on NAFLD has been limited. Safe, inexpensive, and well-tolerated treatments for NAFLD are needed. Recent studies indicate that probiotics help to improve fat breakdown in mice. This study will evaluate the efficacy of probiotic therapy to reduce fat accumulation in the livers of people with NAFLD and diabetes. Participants in this study will be randomly assigned to receive either a probiotic-containing mixture or placebo once daily for 6 months. Blood tests, and magnetic resonance spectroscopy will be used to assess participants at study start and at study completion.


Criteria:

Inclusion Criteria: - Nonalcoholic fatty liver disease Exclusion Criteria: - Any cause of liver disease other than hepatic steatosis - Diabetes - Known or suspected cirrhosis - Inability or unwillingness to undergo magnetic resonance procedures - Requirement of long-term antibiotic therapy - Pregnancy, breast-feeding, or plans to become pregnant


NCT ID:

NCT00068094


Primary Contact:

Principal Investigator
Steve Solga, MD
Johns Hopkins University


Backup Contact:

N/A


Location Contact:

Baltimore, Maryland 21205
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 12, 2017

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