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Corvallis, Oregon 97331


The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements. Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted vitamin E metabolite in the urine.

Study summary:

We will be investigating the fractional disappearance rate of tocopherols in cigarette smokers compared to nonsmokers. This will be accomplished by supplementing individuals with deuterium labeled alpha- and gamma-tocopherols. Quantification of plasma tocopherols as well as urinary metabolites, alpha- and gamma-carboxy ethyl hydroxychromanol, will be determined using liquid chromatography/mass spectrometry analysis. In addition, the role of vitamin C as it pertains to its influence on the fraction disappearance rate of vitamin E will also be evaluated.


Inclusion criteria: - non-smoking status or smokers (more than 1 pack per day) - age: 18-35 y - stable body weight, ranging between 80% and 130%, - maintenance of normal exercise and activity patterns - total cholesterol ≤ 7.758 mmol/L (300 mg/dl) - triglyceride concentration ≤ 3.387 mmol/L (300 mg/dl) Subjects will be excluded if they fulfill any one of the following: - antioxidant supplement users - resting blood pressure above 160/105 mm Hg - engaged in aerobic activity more than five hours per week - vegetarian or other restrictive dietary requirements - fasting blood glucose concentration of ≥ 7.77 mmol/L (140 mg/dl) - history of diabetes or uremia - other known metabolic disease or medication use known to affect lipid metabolism



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Corvallis, Oregon 97331
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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