Expired Study
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Watertown, Massachusetts 02472


Purpose:

The Children's Amalgam Trial is one of only two randomized trials of its kind, and the only such trial in the United States, to address the potential impact of mercury exposure from amalgam restorations on neuropsychological and renal function in children.


Study summary:

The safety of silver amalgam as a dental restorative material has been controversial since its introduction 150 years ago, but until recently it has been assumed that the exposure to mercury from dental amalgam is limited to the acute placement phase. However, some recent studies have raised safety concerns by demonstrating chronic release of mercury vapor from amalgam fillings during chewing and brushing. The Children's Amalgam Trial (CAT) is a two-arm randomized trial of safety, comparing amalgam with a mercury-free restorative material. A single masking procedure is used to ensure that all investigators and staff measuring outcomes are unaware of assigned trial arm. The study follows 534 New England children, aged 6-10 years at enrollment, for 5 years. The children were recruited from two northeastern U.S. communities, one in rural Maine, and one in urban Massachusetts. No trial subjects received prior amalgam restorations, and all were in need of at least two posterior occlusal fillings. Participants were randomized to receive either amalgam or composite material for all posterior restorations at baseline and at subsequent visits. The primary endpoint will be 5-year change in IQ scores. Secondary endpoints will include measures of other neuropsychological assessments and renal functioning.


Criteria:

- 6 - 10 years of age at last birthday - Fluent in English - No prior or existing amalgam restorations - Two or more posterior teeth with dental caries such that restoration would include the occlusal surfaces - No clinical evidence of existing psychological, behavioral, neurologic, immunosuppressive, or renal disorders.


NCT ID:

NCT00065988


Primary Contact:

Principal Investigator
Sonja M McKinlay
New England Research Institutes, Inc


Backup Contact:

N/A


Location Contact:

Watertown, Massachusetts 02472
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 12, 2017

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