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Cleveland, Ohio 44106


This study will compare triple and double drug regimens in the treatment of patients with depression, hypomania, or mania.

Study summary:

Early studies have shown lithium to produce a high percentage of satisfactory clinical response in patients with bipolar disorders. These studies, however, do not include lithium-refractory subgroups, such as bipolar II disorder patients. When the wide spectrum of bipolar disorders is considered, the lithium response rate decreases significantly. More broadly effective regimens are needed. Participants in this study will be randomly assigned to receive either lithium plus divalproex or lithium, divalproex, and lamotrigine for 7 months. Symptoms of depression and mania will be assessed with scales and patient questionnaires.


Inclusion Criteria: - Bipolar I or II Disorder - Meet criteria for rapid cycling, defined as four or more episodes over the past 12 months - Meet criteria for a major depressive episode Exclusion Criteria: - History of intolerability of lithium, divalproex, or lamotrigine



Primary Contact:

Principal Investigator
Keming Gao, MD, PhD
Case Western Reserve University / University Hospitals of Cleveland

Backup Contact:


Location Contact:

Cleveland, Ohio 44106
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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