Expired Study
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Cleveland, Ohio 44106


Purpose:

RATIONALE: Tipifarnib may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth. Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by reducing the production of estrogen. Combining tipifarnib with letrozole may kill more tumor cells. PURPOSE: Randomized phase II trial to compare the effectiveness of letrozole with or without tipifarnib in treating women with locally advanced, locally recurrent, or metastatic breast cancer that has progressed after antiestrogen therapy.


Study summary:

OBJECTIVES: - Compare the efficacy of letrozole with or without tipifarnib based on an objective response rate in women with locally advanced, locoregionally recurrent, or metastatic breast cancer that has progressed after antiestrogen therapy. - Compare the time to progression, time to treatment failure, and survival in patients treated with these regimens. - Compare the clinical benefit rate in patients treated with these regimens. - Compare the duration of response and duration of clinical benefit in patients treated with these regimens. - Compare the safety and tolerability of these regimens in these patients. - Determine the pharmacokinetics of tipifarnib in these patients. OUTLINE: This is a randomized, double-blind, multicenter study. Patients are randomized to 1 of 2 treatment arms. - Arm I: Patients receive oral letrozole once daily and oral placebo twice daily on days 1-21. - Arm II: Patients receive oral letrozole once daily and oral tipifarnib twice daily on days 1-21. Courses in both arms repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients are followed at 30-42 days and every 6 months thereafter. PROJECTED ACCRUAL: Approximately 120 patients (40 for arm I and 80 for arm II) will be accrued for this study.


Criteria:

DISEASE CHARACTERISTICS: - Histologically or cytologically confirmed breast cancer in 1 of the following disease states: - Locally advanced - Locoregionally recurrent - Metastatic - Documented disease progression on or after antiestrogen therapy, given in 1 of the following ways: - As adjuvant therapy (for at least 12 months) - As first-line therapy for advanced disease, on which the patient had an objective response (partial or complete) or stable disease for at least 6 months - Measurable disease - If the sole indicator lesion is in a previously irradiated area, recurrence of the lesion must be biopsy proven - No rapidly progressive, life-threatening metastases, including: - CNS metastases - Diffuse lymphangitis carcinomatosa of the lung - Metastases occupying more than 1/3 of the liver - Hormone receptor status: - Estrogen receptor- or progesterone receptor-positive (i.e., primary or secondary tumor tissue positive by any assay) PATIENT CHARACTERISTICS: Age - See Menopausal status Sex - Female Menopausal status - Postmenopausal, defined as any of the following: - Over 50 years of age and no menstruation for more than 12 months - Any age with castrate levels of follicle-stimulating hormone - Underwent prior bilateral oopherectomy Performance status - ECOG 0-2 Life expectancy - Not specified Hematopoietic - Absolute neutrophil count normal - Platelet count normal Hepatic - Bilirubin no greater than 2 mg/dL - AST and ALT no greater than 2.5 times upper limit of normal (ULN) Renal - Creatinine no greater than 1.5 times ULN Other - No other malignancy within the past 5 years except contralateral breast carcinoma, basal cell or nonmetastatic squamous cell skin cancer, carcinoma in situ of the cervix, or stage I carcinoma of the cervix - No symptomatic peripheral neuropathy - No known or suspected allergy to letrozole or imidazole drugs (e.g., clotrimazole, ketoconazole, miconazole, econazole, fenticonazole, isoconazole, sulconazole, tioconazole, or terconazole) - No coexisting medical condition that would interfere with study procedures and/or results PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - No more than 1 prior chemotherapy regimen, given as adjuvant therapy or for metastatic disease (not both) Endocrine therapy - See Disease Characteristics - No prior systemic endocrine therapy (including aromatase inhibitors) except antiestrogen therapy (e.g., tamoxifen) Radiotherapy - See Disease Characteristics Surgery - Not specified Other - At least 30 days since prior participation in another investigational study - No prior farnesyl transferase inhibitor therapy - No other concurrent anticancer treatment - Concurrent bisphosphonates allowed for bone metastases present at baseline


NCT ID:

NCT00060177


Primary Contact:

Study Chair
Paula Silverman, MD
Case Comprehensive Cancer Center


Backup Contact:

N/A


Location Contact:

Cleveland, Ohio 44106
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 17, 2017

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