RATIONALE: Genetic studies may help in understanding the genetic processes involved in the
development of some types of cancer.
PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer
or adenomatous polyps.
- Identify human colon neoplasia susceptibility genes in patients with colon cancer or
- Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of
the colon with colon neoplasia in these patients.
- Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT
genes in these patients.
- Identify a novel gene that governs increased susceptibility to colon adenoma and cancer
in the genome of these patients.
- Diagnosis of colon cancer or polyps at age 70 or under
- Has a living full sibling with diagnosis of colon cancer or polyps at age 70 or under
- No history of familial adenomatous polyposis syndrome
- No hereditary nonpolyposis colon cancer, according to Amsterdam criteria
- No known I1370K adenomatous polyposis of the colon susceptibility variant
- Enrolled on 1 of the following clinical trials:
- CLB-80001 NOTE: Patients do not need to be receiving protocol therapy. Patients
who are outside the treatment protocol's follow-up range are eligible. Patients
who discontinued therapy for any reason, including toxic effects, are eligible.
- 70 and under at diagnosis
- No significant psychiatric illness that would preclude giving informed consent
- No inflammatory bowel disease (in patient or sibling)