This research trial studies tissue samples from patients with ovarian cancer in the
laboratory. Analyzing tissue samples from patients in the laboratory may help doctors learn
more about cancer.
I. Utilize array comparative genomic hybridization and Taqman analyses, a quantitative
genomic polymerase chain reaction, to validate the observation that a gain in chromosome 8q
is predictive of shorter progression-free survival in patients with primary grade 2 or grade
3 advanced serous papillary ovarian cancer.
II. Utilize these analyses to determine whether a gain in chromosome 8q is predictive of
worse overall survival in these patients.
III. Utilize these analyses to determine whether other previously identified chromosomal
changes (3q gain, 7q gain, 16q loss, and 17pter-q21 loss) predict outcome in these patients
and the association between these changes and clinical characteristics.
IV. Utilize these analyses to identify up to 5 additional chromosomal changes and their
association that may predict outcome (progression-free and overall survival) in these
Genomic DNA is isolated from optimal cutting temperature (OCT)-embedded tissue and analyzed
using comparative genomic hybridization. The chromosomal changes identified by this method
are compared to those identified using the Taqman method, a quantitative genomic polymerase
chain reaction analysis. Chromosome 8q is of specific interest. Other chromosomal changes
may be detected in chromosomes 3q, 7q, 16q, and/or 17pter-q21.
- Stage III or IV, high-grade (grade 2 or 3) ovarian cancers
- No borderline or low-grade (grade 1) tumors
- Tissue from predominately serous ovarian cancer only
- No clear cell, endometrioid, mucinous, transitional cell, or mixed without
predominant serous component
- Tissue obtained during prior optimal or suboptimal cytoreductive surgery
- Must be enrolled on GOG-0136 and a GOG front-line paclitaxel/platinum chemotherapy
- Frozen tissue and hematoxylin-eosin stained section from the ovary obtained at
- Performance status - GOG 0-2