Expired Study
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Indianapolis, Indiana 46202


Purpose:

The purpose of this study is to determine the safety and efficacy of rhAngiostatin protein administered in combination with paclitaxel and carboplatin to patients with non-small-cell lung cancer.


Criteria:

Inclusion: - Histological or cytological confirmed Stage IIIB NSCLC with malignant pleural effusions, or Stage IV NSCLC or recurrent NSCLC - No previous chemotherapy for NSCLC - Have one lesion that is bidimensionally measurable by physical exam, MRI, or CT greater than 1 cm in diameter - Specified lab parameters - Life expectancy of at least 12 weeks - ECOG performance status of 0 or 1 - Understand requirements of study - Agree to use effective contraceptive methods Exclusion: - Have CNS metastases - Have any active cancer in addition ot NSCLC - Participated in clinical trial involving conventional or investigational drugs within previous 4 weeks - Have any contraindication to paclitaxel or carboplatin - Have had Grade 3 or greater peripheral neuropathies - Be pregnant or lactating - Have a history of myocardial infarction or angina pectoris/angina in the last 6 months - Have had significant (30 mL or more) hemoptysis with the past 3 months - Have an active infection - Have a history of bleeding diathesis, hypercoagulable condition, or an active bleeding disorder - Be receiving concurrent treatment with therapeutic doses of heparin or coumadin - Have had major surgery within 4 weeks of stating therapy - Have additional uncontrolled serious medical conditions or psychiatric illness - Received rhAngiostatin in other clinical protocols


NCT ID:

NCT00049790


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Indianapolis, Indiana 46202
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 10, 2017

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