Expired Study
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Houston, Texas 77030


Purpose:

Objectives: 1. Determine the toxicity of infusions of allogeneic donor lymphocytes activated by acute leukemia derived dendritic cells (DC/ADL) in relapsed patients after allo-stem cell transplants. 2. Quantitate the alloreactivity of DC/ADL and circulating immune effector cells in patients after infusion. 3. Assess efficacy of acute myelogenous leukemia (AML) or Chronic Myelogenous Leukemia in Blastic Crisis (CML-BC) derived dendritic cells and activated lymphocytes in promoting and sustaining remission in patients with relapse after allo-BMT or stem cell transplant.


Criteria:

Inclusion Criteria: - AML (any type except M3) or CIVIL in blast crisis with greater than or equal to 20% bone marrow blasts at the time of related donor marrow or stem cell transplantation or at relapse post transplant. - Willing to undergo a skin biopsy and either a leukodepletion apheresis or an additional marrow aspiration. - Stem cell or marrow donor willing to have apheresis for T-Cell collection. - Written voluntary informed consent must be obtained from patient and donor. Exclusion Criteria: - Medical, social or psychologic factors which would prevent the patient from receiving or cooperating with the full course of therapy or understanding the informed consent procedure. - AML French-American-British (FAB) subtype M3.


NCT ID:

NCT00048100


Primary Contact:

Principal Investigator
Elizabeth J. Shpall, MD
UT MD Anderson Cancer Center


Backup Contact:

N/A


Location Contact:

Houston, Texas 77030
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: December 11, 2017

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