To find out if it is safe and effective to use smoked marijuana in combination with opioids
to treat cancer pain. The study will evaluate whether smoked marijuana, when used with
opioids, will have an effect on pain relief, and to see if marijuana reduces the side
effects of opioids, which include nausea and/or vomiting.
To take part in this study, you must have ongoing cancer pain which is currently being
treated with opioids. If you meet all the eligibility criteria you will be admitted to the
General Clinical Research Center at San Francisco General Hospital for 9 days. The
treatment consists of smoking one marijuana cigarette 3 times a day.
- Have ongoing cancer pain
- Be diagnosed with cancer and have at least a six month survival.
- Be on a stable dose of opioid medication for at least 2 weeks before enrollment.
- Have smoked marijuana on at least 6 occasions in their lifetime prior to enrollment.
You must not:
- Start chemotherapy, radiation or biphosphonates during the study, or have received
any new intervention with any such agents within the past 4 weeks.
- Currently be using smoked tobacco products.
- Currently be in methadone treatment.
- Have smoked marijuana within 30 days of enrollment.
- Be diagnosed with diabetes mellitus.
- Have severe heart disease, uncontrolled hypertension, or lung disease.
- Currently be receiving treatment with corticosteroids.
- Be pregnant or breastfeeding.