The purpose of this study is to determine whether short-term use of the drugs ibuprofen and
lovastatin affects levels of a protein called beta-amyloid in people who are at risk for
developing Alzheimer's Disease (AD).
There is increasing evidence that nonsteroidal and cholesterol lowering medications may be
associated with a delay in the onset of Alzheimer's disease (AD). There is separate evidence
that beta-amyloid(1-42) is involved in the pathophysiology of AD and levels of
beta-amyloid(1-42) in the cerebrospinal fluid (CSF) of AD patients are significantly lower
than that found in controls. It has been suggested that these standard medications may have
indirect effects that alter the normal course of AD, but there is no data to directly
support this contention in humans. Based on previous work, it is our hypothesis that CSF
beta-amyloid(1-42) levels may serve as an early biomarker of AD. Any pharmacological induced
change in CSF beta-amyloid(1-42) might have profound implications for the eventual onset of
illness. Therefore, the purpose of this study is to evaluate the short-term effects of two
commonly prescribed nonsteroidal and cholesterol lowering medications, ibuprofen and
lovastatin, on the levels of cerebrospinal fluid beta-amyloid(1-42) in a group of normal
controls 'at risk' for developing AD.
1. Normal volunteer over the age of 18
2. Cognitively within normal limits at baseline evaluation
3. Previously evaluated in Protocol 95-M-0096
4. Women of child-bearing potential will be advised not to become pregnant during the
1. Known allergies to lovastatin or ibuprofen
2. Use of regular dosing of NSAID or statin during the previous month
3. Concurrent use of cyclosporine, itraconazole, ketoconazole, gemfibrozil, niacin,
erythromycin, clarithromycin, HIV protease inhibitors or nefazodone because of
possible drug interactions with lovastatin.
4. Women who are currently pregnant
5. Concurrent use of anticoagulants, aspirin, beta-adrenergic agents, cimetidine,
digoxin and oral hypoglycemics because of possible drug interactions with ibuprofen.
6. Peptic ulcer disease by history
7. Autoimmune disease by history