The purpose of this study is to test the use of time-released bupropion (Wellbutrin) in
patients receiving treatment for alcohol abuse/dependence as an aid to stop smoking.
Patients will receive either a time-released bupropion or placebo. Both groups will receive
nicotine replacement therapy during the 9 week study. A final followup assessment will be
conducted 6 months from the start of treatment.
- Currently a patient in the Omaha VA Medical Center, Substance Abuse Treatment Center
(SATC) or at Catholic Charities Campus for Hope.
- Have a diagnosis of alcohol abuse or alcohol dependence.
- Smoke 20 or more cigarettes/day (may also smoke pipes/cigars).
- Be interested in quitting smoking.
- Provide name, addresses, and phone numbers of at least two individuals who can
provide information on their alcohol, nicotine, and other drug use during the
- If female, patient must a) be of non-childbearing potential, b) have a negative
pregnancy test, c) sign a document stating they do not plan on becoming pregnant
during the study.
- Agree to sign informed consent.
- Able to read and understand study-related forms and procedures.
- Advanced cardiac, pulmonary, renal, or liver disease.
- History of seizures.
- History of brain tumor or significant head trauma.
- History of bulimia or anorexia nervosa.
- Current major depressive disorder or past history of panic disorders, schizophrenia,
or bipolar affective disorder.
- Using psychoactive drugs.
- Receiving treatment with medications that lower seizure thresholds.
- Use of an investigational drug in any study in the past four weeks.
- Currently using any asthma medication.
- Used time-released bupropion in the past 12 months.
- Currently using any other treatments to stop smoking.