A molecular epidemiologic study of African American and Hispanic mothers and newborns to
investigate the role of common urban pollutants on procarcinogenic and developmental damage.
The major objective of the proposed research is to study the impact of early-life exposures
to common urban pollutants on neurobehavioral development and asthma in a sample of children
living in three low-income, minority communities of New York City (Central Harlem,
Washington Heights and the South Bronx). Using a molecular epidemiologic approach with
monitoring, biomarkers, and clinical assessments at serial time points, we will extend our
study of African-American and Latina urban mothers and children in order to follow the
cohort through child age 11 years to assess the longer-term impact of exposures on child
health and developmental outcomes.
Enrollment eligibility was restricted to nonsmoking pregnant women 18-35 years of age who
self-identified as either African American or Dominican and who had resided in northern
Manhattan or the South Bronx in New York City for at least 1 year before pregnancy. Women
were excluded if they used illicit drugs, had diabetes, hypertension, or known HIV, or had
their first prenatal visit after the 20th week of pregnancy.