The purpose of this study is to see if a novel 4-drug anti-HIV combination can suppress the
growth of HIV in patients infected with the virus.
- Have HIV Infection.
- Age 18 to 65 years old.
- Show no signs of recent illness other than HIV infection.
- Agree to use a barrier method of birth control during the study and for 30 days after
- Are unable to follow study requirements (in the opinion of the investigator).
- Are pregnant or breast-feeding.
- Are unable to take medications by mouth.
- Have chronic nausea or vomiting.
- Have cancer other than Kaposi's sarcoma or basal cell carcinoma.
- Have active, serious infections (other than HIV) requiring antibiotic injections
within 15 days prior to screening.
- Are taking any medications that are not allowed with ABT-378/r and efavirenz.
- Are taking or have taken any other experimental drugs, antiretroviral drugs, or drugs
that affect the immune system within 30 days of start of study without consent of the
- Are receiving or have received radiation therapy within 30 days of start of study
without consent of the medical monitor.
- Have a history of drug abuse or mental illness that would prevent the patient from
following the protocol requirements.
- Have a history of kidney or bone disease.