The purpose of this study is to assess the efficacy of ZD6474 in patients with metastatic
breast cancer at 2 dose levels.
- Histological and/or cytological confirmation of metastatic breast cancer which is
refractory to anthracycline, taxane, with or without capecitabine therapies;
- WHO performance status 0, 1 or 2 on the day of registration;
- Females, aged >= 18 years;
- No Gastrointestinal pathology which could affect the bioavailability of ZD6474.
- Any evidence of severe or uncontrolled systemic diseases including known cases of
Hepatitis B or C or human immunodeficiency virus (HIV).
- Significant cardiac event (including symptomatic heart failure or unstable angina)
within 3 months of entry or any cardiac disease that in the opinion of the
investigator increases risk for ventricular arrhythmia;
- History of clinically significant cardiac arrhythmia (multifocal PVCs, bigeminy,
trigeminy, ventricular tachycardia), which is symptomatic or requires treatment (CTC
grade 3) or asymptomatic sustained ventricular tachycardia;
- Chronic atrial fibrillation;
- Previous history of QT / QTc prolongation with other medication;
- Congenital long QT syndrome;
- Systemic anti-cancer therapy or other investigational agent within the last 4 weeks
(6 weeks for nitrosoureas, mitomycin C, or suramin);
- Currently receiving drugs with known significant 3A4 inhibitory (ie, ketoconazole,
itraconazole, troleandomycin, erythromycin, diltiazem, verapamil) or stimulatory (ie,
phenytoin, carbamazepine, barbiturates, rifampicin) effects;
- Currently receiving therapeutic doses of warfarin (Coumadin?)