The purpose of this study is to assess the efficacy and safety of ondansetron to reduce
cocaine use in subjects with cocaine dependence.
Double-blind, placebo-controlled, 4-parallel group design to assess the efficacy and safety
of 3 wide range doses of ondansetron to reduce cocaine use in subjects with cocaine
dependence and to determine the optimal dose of ondansetron.
Male/Female, at least 18 yrs of age; DSM-4 diagnosis of cocaine dependence; seeking
Treatment for cocaine dependence; have ability to understand, having understood and
provide written consent; females of child bearing potential that use accepted method of
Additional criteria available during screening at the site.