The purpose of this study is to evaluate modafinil, a cocaine treatment medication, and its
interactions with intravenous (IV) cocaine.
Placebo-controlled, escalating dose drug interaction study using a total of 12 cocaine users
at a single site. Study duration will include four infusion sessions: 1) screening/baseline;
2) baseline; 3) 400mg/day steady-state modafinil; 4) 800 mg/day steady state modafinil.
Infusion session will be 2 days in duration.
Dependent on cocaine; non-treatment seeking; male or female; DSM-4 criteria for cocaine
abuse or dependence; at least 18 years of age but no older than 45 non-pregnant females
using adequate birth control; capable of providing written informed consent; able to
comply with protocol requirements.
Additional criteria available during screening at the site