This study will use magnetic resonance imaging (MRI) to investigate how the brain controls
bimanual movements (movements of both hands).
Healthy normal volunteers between 21 and 65 years of age may be eligible for this study.
Participants will have a medical history, physical and neurological examinations, and will
complete a questionnaire before and after testing. The study consists of two parts: 1)
finger movement training and 2) magnetic resonance imaging, as follows:
Part 1 - Finger movement training
Participants will train to do three different finger movements using the index finger of
both hands. The fingers will be taped to a device that measures their movement. The
- Lifting and dropping the index fingers of each hand repetitively and in synchrony
(starting and stopping at the same time). The amplitude of finger movements is the same
for both hands.
- Lifting and dropping the index fingers of each hand repetitively and in synchrony, but
with a different amplitude for each hand.
- Lifting and dropping of the index finger of each hand repetitively, but each with a
different amplitude and not in synchrony.
Part 2 - Magnetic resonance imaging
Participants will perform the trained movements during MRI scanning. This diagnostic
procedure uses a magnetic field and radio waves to produce images of brain structure and
activity. For MRI, the subject lies on a stretcher that is moved into the scanner-a cylinder
containing a strong magnet. Earplugs are worn to protect the ears from loud thumping noises
that occur with electrical switching of radio frequency circuits. Scanning time varies from
20 minutes to 2 hours, with most examinations lasting 1 to 1 1/2 hours. The subject can
communicate with the staff person conducting the test at all times during the scan.
OBJECTIVE: The present study is aimed to clarify which structure or network of structures
are responsible for the temporal linkage in bimanual co-ordination in healthy humans.
STUDY POPULATION: Healthy normal volunteers.
fMRI: Anatomical MRI and fMRI sequences are performed to obtain blood-oxygenation
level-dependent (BOLD) imaging of brain activation during which movement performance will be
measured with respect to movement synchrony, movement speed and amplitude.
Multi-channel EEG recording performed while motor performance is monitored.
fMRI: BOLD will be obtained using baseline correction.
EEG: band-power and inter-regional coherence will be calculated using baseline correction.
- INCLUSION CRITERIA:
1. Forty normal volunteers ranging from 21 to 75 will be included. Normal
volunteers would be recruited from people who are registered as HMCS Normal
Volunteers. All subjects should have a valid Clinical Center Medical Record
2. Alcohol abstention is required for all subjects for both fMRI and EEG for 24
hours before the study.
1. Normal subjects younger than 21 years and older than 75 will also be excluded from
the study since development and decline in movement performance and the associated
brain activation is out of the scope of the present study.
2. Normal subjects with MRI findings consistent with organic brain lesions such as brain
tumors, stroke, trauma or AVMs will be excluded.
3. Normal subjects with a history of significant medical disorders such as cancers, or
requiring continuous treatment with drugs will be excluded.
4. Subjects with mental disorders will be excluded.
5. We will not scan pregnant women because safety of high magnetic field to fetus is not
established. Therefore, we will administer a urine pregnancy test for any female
subjects of childbearing potential 24 hours prior to functional MRI scan. Pregnant
women will not be excluded from the EEG arm of this protocol.