Bethesda, Maryland 20892


Purpose:

Background: -Research in NCI's Radiation Oncology Branch depends on the availability of blood and urine samples from patients receiving radiation therapy. Objectives: -To explore the effects of radiation therapy on gene expression in white blood cells, to measure radiation damage in red blood cells and to examine changes in hormone levels in the blood and urine after radiation therapy. Eligibility: -Patients 18 years of age and older who are receiving radiation therapy. Design: - Blood and urine samples are collected when participants enter the study. - Additional samples may be collected at different times during and after treatment. Ideally, samples are obtained before, at the completion of, and 1 month following radiation therapy. Blood samples usually will be collected during routine patient monitoring procedures and will not require an additional needle stick. - A total of 300 patients will be studied at the NCI in Bethesda, MD, Johns Hopkins University in Baltimore and the University of Pennsylvania in Philadelphia.


Study summary:

BACKGROUND: Evolving research initiatives in the Radiation Oncology Branch (ROB) NCI, depend upon the availability of blood and urine samples from patients receiving radiotherapy. Examples of planned studies include an exploration of the effects of radiotherapy on peripheral leukocyte phenotype, peripheral blood protein and metabolism changes as well as measurements of matrix metalloproteinases (MMP) in urine. OBJECTIVES: This protocol provides a means of acquiring blood and urine samples in patients receiving radiation therapy for a variety of conditions. ELIGIBILITY: Patients seen in the radiation oncology clinic will be asked to donate blood and/or urine before, during and after their treatment. DESIGN: This is a pilot, exploratory study to evaluate the effects of ionizing radiation in blood and/ or urine. On most occasions, the blood samples will be obtained as a component of routine patient monitoring and will not necessitate an additional venipuncture. Blood and urine samples will be processed and stored in the Radiation Oncology Branch and Basic Research Laboratory, CCR, NCI, for use in the research efforts of the branch.


Criteria:

- INCLUSION CRITERIA: 1. Patients must a candidate for, or currently receiving radiotherapy. 2. Age greater than or equal to 18 years. EXCLUSION CRITERIA: 1. Inability to provide informed consent. 2. Patients who have unobtainable data regarding previous radiation therapy.


NCT ID:

NCT00027326


Primary Contact:

Principal Investigator
Kevin A Camphausen, M.D.
National Cancer Institute (NCI)

Theresa Cooley-Zgela, R.N.
Phone: (240) 760-6207
Email: theresa.cooleyzgela@nih.gov


Backup Contact:

Email: camphauk@mail.nih.gov
Kevin A Camphausen, M.D.
Phone: (240) 760-6205


Location Contact:

Bethesda, Maryland 20892
United States

For more information at the NIH Clinical Center contact National Cancer Institute Referral Office
Phone: (888) NCI-1937

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: December 16, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.