Expired Study
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Bethesda, Maryland 20892


Purpose:

RATIONALE: The BL22 immunotoxin can locate tumor cells and kill them without harming normal cells. PURPOSE: Phase I trial to study the effectiveness of the BL22 immunotoxin in treating patients who have non-Hodgkin's lymphoma or chronic lymphocytic leukemia.


Study summary:

OBJECTIVES: - Determine the toxicity and therapeutic efficacy of recombinant BL22 immunotoxin in patients with CD22-positive B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia. - Determine the pharmacokinetics, including the terminal elimination serum half-life area under the curve and volume of distribution, of recombinant BL22 immunotoxin in these patients. - Determine the immunogenicity of recombinant BL22 immunotoxin in these patients. - Determine the effect of recombinant BL22 immunotoxin on various components of the circulating cellular immune system in these patients. OUTLINE: This is a dose-escalation study. Patients receive recombinant BL22 immunotoxin IV over 30 minutes on days 1, 3, and 5. Patients may be retreated at least every 20 days for up to 25 courses in the absence of disease progression and sufficient neutralizing antibodies. Cohorts of 3-6 patients receive escalating doses of recombinant BL22 immunotoxin until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study within 2 years.


Criteria:

DISEASE CHARACTERISTICS: - Histologically confirmed chronic lymphocytic leukemia or prolymphocytic leukemia: - Failed prior standard chemotherapy and treatment is medically indicated as evidenced by the following: - Progressive disease-related symptoms - Progressive cytopenias due to marrow involvement - Progressive or painful splenomegaly or adenopathy - Rapidly increasing lymphocytosis - Autoimmune hemolytic anemia or thrombocytopenia - Increased frequency of infections OR - Confirmed CD22+ B-cell indolent non-Hodgkin's lymphoma - Stages II-IV that have failed at least 1 prior standard therapy and treatment is medically indicated - No patients whose serum neutralizes BL22 or PE38 in tissue culture, due to antitoxin or antimouse-IgG antibodies - No central nervous system disease requiring treatment - If the patient is non-leukemic, the absolute neutrophil count must be greater than 1,000/mm3 and the platelet count greater than 40,000/mm3 PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - Karnofsky 60-100% Life expectancy: - More than 6 months Hematopoietic: - See Disease Characteristics Hepatic: - ALT and AST less than 5 times upper limit of normal Renal: - Adequate renal function Pulmonary: - Adequate pulmonary function Other: - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy: - Prior bone marrow transplantation allowed - At least 3 weeks since prior interferon for malignancy Chemotherapy: - See Disease Characteristics - At least 3 weeks since prior cytotoxic chemotherapy for malignancy Endocrine therapy: - Not specified Radiotherapy: - At least 3 weeks since prior radiotherapy for malignancy Surgery: - Not specified Other: - At least 3 weeks since prior retinoids - At least 3 weeks since prior systemic therapy for cancer


NCT ID:

NCT00024115


Primary Contact:

Study Chair
Robert Kreitman, MD
National Cancer Institute (NCI)


Backup Contact:

N/A


Location Contact:

Bethesda, Maryland 20892
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 24, 2017

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