Expired Study
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Los Angeles, California 90095


Purpose:

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Celecoxib may be effective in preventing lung cancer in tobacco smokers. PURPOSE: Phase II trial to study the effectiveness of celecoxib in preventing non-small cell lung cancer in tobacco smokers.


Study summary:

OBJECTIVES: - Determine the efficacy and feasibility of celecoxib for chemoprevention of primary non-small cell lung cancer in high-risk tobacco smokers. - Determine the safety and long-term side effects of this drug in this population. OUTLINE: Patients receive oral celecoxib twice daily for 6 months. Patients are followed at 2 weeks and then at 6 months. PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study within 6 months.


Criteria:

Inclusion Criteria: - Age > 45 - Smoked > 20 pack years Exclusion Criteria: - Concurrent use of NSAIDs - Hypersensitivity to celecoxib - Documented allergic-type reaction to sulfonamides - History of allergic reaction, urticaria or asthma to aspirin or other NSAIDs - History of liver dysfunction - Hypertension or cardiac conditions aggravated by fluid retention and edema - Previous history of gastrointestinal ulceration, bleeding, or perforation - Renal dysfunction - End stage respiratory disease - Unstable angina - Other malignancy - Pregnancy - Concurrent use of medication known to alter or be affected by alteration of the hepatic p450 2C9 and 2D6 enzymes - Patents with concurrent medical conditions that may interfere with completion of tests, therapy, or the follow up schedule


NCT ID:

NCT00020878


Primary Contact:

Principal Investigator
Jenny T. Mao, MD
Jonsson Comprehensive Cancer Center


Backup Contact:

N/A


Location Contact:

Los Angeles, California 90095
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 19, 2017

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