Expired Study
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Bethesda, Maryland 20892


Purpose:

RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Interleukin-2 may stimulate a person's white blood cells to kill tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of vaccine therapy with and without interleukin-2 in treating patients who have metastatic melanoma that has not responded to previous treatment.


Study summary:

OBJECTIVES: - Determine efficacy of recombinant fowlpox and vaccinia viruses encoding tyrosinase antigen, administered with or without low-dose interleukin-2 (IL-2), in terms of response, in patients with metastatic melanoma. - Compare the response rate in patients to this vaccination administered with high-dose IL-2 to that in similar patients on previous trials treated with high-dose IL-2 alone. - Determine the immunological response in patients treated with this regimen. OUTLINE: This is a randomized study. Patients are randomized to one of three treatment arms. - Arm I: Patients receive recombinant fowlpox vaccine IM on day 1 followed 4 weeks later by recombinant vaccinia vaccine IM. Treatment repeats for a minimum of 4 vaccinations. - Arm II: Patients receive vaccinations as in arm I plus low-dose interleukin-2 (IL-2) subcutaneously daily on days 2-13 after each vaccination. - Arm III: Patients receive vaccinations as in arm I plus high-dose IL-2 IV over 15 minutes every 8 hours on days 2-5 after each vaccination. Patients with stable disease or a minor, mixed, or partial response after four immunizations (1 course) may receive a second course of the same regimen beginning 4-6 weeks after the first course. After the second course, patients with tumor regression may continue to receive treatment in the absence of unacceptable toxicity until best response is achieved. Patients are followed at 4-6 weeks. PROJECTED ACCRUAL: A total of 73 patients (13-20 for arm I, 13-20 for arm II, and 19-33 for arm III) will be accrued for this study within 2 years.


Criteria:

DISEASE CHARACTERISTICS: - Histologically confirmed metastatic melanoma that has failed standard treatment - No ocular or mucosal melanoma as primary site - Measurable disease - No existing brain metastases PATIENT CHARACTERISTICS: Age: - 16 and over Performance status: - ECOG 0 or 1 Life expectancy: - More than 3 months Hematopoietic: - WBC at least 3,000/mm3 - Platelet count at least 90,000/mm3 - No coagulation disorder Hepatic: - Bilirubin no greater than 1.6 mg/dL - AST/ALT less than 3 times normal - Hepatitis B surface antigen negative Renal: - Creatinine no greater than 1.6 mg/dL Cardiovascular: - No major cardiovascular illness Pulmonary: - No major respiratory illness Immunologic: - HIV negative - No autoimmune disease - No primary or secondary immunodeficiency - No allergy to eggs - No history of allergy or untoward reaction to prior smallpox vaccination Other: - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - Must be able to avoid close contact with children under 5 years, pregnant women, people with active or a past history of eczema or other eczematoid skin disorders, and immunosuppressed people for at least 2 weeks after each vaccinia virus vaccination - No active systemic infections - No active atopic dermatitis or active or past history of eczema - No concurrent active extensive psoriasis, severe acneiform rash, impetigo, varicella zoster, burns, or other traumatic or pruritic skin conditions or open wounds - Surgical scars must be healed - Healed surgical stomas (e.g., colostomy) allowed PRIOR CONCURRENT THERAPY: Biologic therapy: - No prior recombinant vaccinia or fowlpox vaccines for melanoma - At least 3 weeks since prior systemic biologic therapy for melanoma Chemotherapy: - At least 3 weeks since prior systemic chemotherapy for melanoma Endocrine therapy: - At least 3 weeks since prior systemic endocrine therapy for melanoma - No concurrent steroid therapy Radiotherapy: - At least 3 weeks since prior systemic radiotherapy for melanoma Surgery: - Prior surgery allowed


NCT ID:

NCT00019734


Primary Contact:

Study Chair
Suzanne L. Topalian, MD
NCI - Surgery Branch


Backup Contact:

N/A


Location Contact:

Bethesda, Maryland 20892
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 20, 2017

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