Expired Study
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Bethesda, Maryland 20892


Purpose:

RATIONALE: Imaging procedures such as MRI may improve the ability to determine the response of brain tumors to therapy. PURPOSE: This clinical trial is studying how well MRI works in evaluating response to therapy in children with primary or metastatic brain tumors.


Study summary:

OBJECTIVES: - Define specific patterns of metabolites using long echo time multislice proton nuclear magnetic resonance spectroscopic imaging. - Attempt to distinguish spectroscopic patterns associated with tumor progression, tumor necrosis, radiation necrosis and tumor edema on conventional MRI imaging. - Determine if early metabolic changes are predictive of response in children with brain tumors treated with chemotherapy. OUTLINE: Patients undergo nuclear magnetic resonance spectroscopic (NMRS) imaging prior to therapy, immediately after the first cycle of therapy, and/or prior to subsequent cycles of therapy. After NMRS imaging, all patients are injected with IV gadolinium-DTPA and postcontrast T1-weighted images are performed. PROJECTED ACCRUAL: Approximately 50 patients will be accrued for this study.


Criteria:

DISEASE CHARACTERISTICS: - Histologically confirmed primary or metastatic brain tumor - Measurable or evaluable - Brain stem glioma patients need no prior histological diagnosis - Concurrent enrollment on a NIH primary brain tumor treatment trial or the Natural History or Standard Therapy protocols PATIENT CHARACTERISTICS: Age: - 21 and under Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified Cardiovascular: - No cardiac pacemakers Pulmonary: - Not specified Other: - Not pregnant - No neural implants, shrapnel, or cochlear implants - No physical or psychological factors interfering with imaging studies - No contraindications to anesthesia - No history of severe reaction to gadolinium or other contrast agents PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - Concurrent chemotherapy allowed Endocrine therapy: - Concurrent immunotherapy allowed Radiotherapy: - Concurrent radiotherapy allowed Surgery: - No metallic implants (e.g., ferrous surgical clips)


NCT ID:

NCT00019292


Primary Contact:

Study Chair
Katherine Warren, MD
NCI - Pediatric Oncology Branch


Backup Contact:

N/A


Location Contact:

Bethesda, Maryland 20892
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 22, 2017

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