The purpose of this study is to determine how people with high triglycerides metabolize and
absorb bile acids, compounds made in the body from cholesterol.
This project has two objectives: A) To define the mechanism of impaired bile acid
absorption in hypertriglyceridemia (specifically we will determine if the active or passive
component of absorption is abnormal) and B) to determine the contribution of an alternative
pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because
27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a
role in removal of cholesterol from incipient atherosclerotic plaque.
Hypertriglyceridemia and normal controls with normal lipids