Motor slowing is a hallmark, clinical sign in mental illness. Slowness can be related to a
specific disease process, as in negative schizophrenia or depression or it can be the result
of medications used to treat forms of mental illness. Prior research has lead to a novel
instrumental approach for distinguishing subtypes of motor slowing - one type related to
cognitive processes and another related to parkinsonism. The purpose of this study is to
test whether new medications used to treat schizophrenia improve the cognitive or
parkinsonian components of motor slowing. Patients will be studied in the laboratory before
and 8-weeks after starting a new antipsychotic. The n of this study = 60 patients. The
results of this study will improve our understanding of the complex interactions between
cognitive processing and motor behavior in patients with psychotic illnesses and how drugs
work to treat these problems.
Schizophrenia diagnosis currently treated with conventional antipsychotic willing to be
switched to an atypical antipsychotic.