This study will use transcranial magnetic stimulation to examine how the brain controls
movement by sending messages to the spinal cord and muscles and what goes wrong with this
process in disease. Normal healthy volunteers 18 years of age and older may be eligible to
In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's
scalp or skin. Brief electrical currents are passed through the coil, creating magnetic
pulses that stimulate the brain. During the stimulation, participants will be asked to
tense certain muscles slightly or perform other simple actions. The electrical activity of
the muscle will be recorded on a computer through electrodes applied to the skin over the
muscle. In most cases, the study will last less than 3 hours.
The purpose of this study is to investigate the influence of volitional movement on
excitability of ipsilateral as well as contralateral motor cortical neurons controlling
homologous and surrounding muscles. Transcallosal and surrounding inhibitions are well
known phenomenon to suppress unwanted movements during voluntary action, which is often
disturbed in various movement disorders. Transcranial magnetic stimulation (TMS) has been
used to investigate these inhibitory mechanisms, but the inhibitory influence during and
after voluntary movement has not been well elucidated yet. In normal volunteers, we plan to
determine if voluntary movements of one finger influence the cortical excitability
responsible for surrounding as well as contralateral homologous muscles, using voluntary
movement-triggered TMS. The primary outcome measures would be any changes in motor evoked
potential (MEP) size and intracortical inhibition (ICI) parameters.
Normal adult volunteers 18 or more years old.
Subjects must not have medico-surgical illness.
Subjects must not have neurological illness.
Subjects must not have psychiatric illness.
Subjects must not be taking any medication with potential influence on nervous system
Subjects must not have a pacemaker.
Subject must not have an implanted medical pump.
Subjects must not have a metal plate or a metal object in the skull or eye.
Subjects must not have a history of seizure disorder.