Expired Study
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Cincinnati, Ohio 45220


The purpose of this study is to determine the efficacy of naltrexone in the treatment of cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2) decreased cocaine use by self-report, 3) decreased cocaine craving, and 4) retention in treatment.

Study summary:

Double-blind, placebo controlled study of the safety and efficacy of naltrexone in treating cocaine dependence in a patient sample that initiated the study while in an inpatient setting and were then followed-up for 3 months as outpatients.


Inclusion Criteria: 1. Meet DSM-III-R criteria for cocaine dependency, 2. 18 to 65 years of age, 3. capable of understanding the study, 4. voluntarily signed consent, 5. male or non-pregnant female using approved form of birth control. Exclusion Criteria: 1. abnormal liver function tests (SGOT, SGPT, or GGT greater than twice the normal values), 2. opioid use within the last 7 days, 3. use of neuroleptics, 4. having a severe acute medical problem, 5. unable to complete psychiatric rating scales, or 6. judged by the investigator to be unlikely to comply with the study protocol



Primary Contact:

Principal Investigator
Eugene Somoza, M.D., Ph.D.
Cincinnati MDRU

Backup Contact:


Location Contact:

Cincinnati, Ohio 45220
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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