The purpose of this study is to determine the efficacy and safety of a
buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for
opiate-dependence treatment. The developmental objective for this combination product is an
expansion of therapeutic options for the treatment of opiate dependence.
This multicenter pivotal clinical trial was comprised of two phases. The first phase, which
was four weeks in length, was double-blind placebo controlled and was primarily used to
evaluate the efficacy of buprenorphine/naloxone. The second phase, lasting 48 weeks, was
primarily conducted to determine the safety of buprenorphine/naloxone.
1. DSM-IV (Diagnostic and Statistical Manual of the American Psychiatric Association)
diagnosis of current opiate dependence.
2. Individuals seeking opiate-substitution pharmacotherapy for opiate dependence.
3. Males and non-pregnant, non-nursing females, 18 to 59 years of age (inclusive).
4. Individuals able to give informed consent and willing to comply with all study
procedures (e.g., providing of urine samples under observation, completing
1. Any acute or chronic medical condition that would make participation in the study
medically hazardous (e.g., acute hepatitis, unstable cardiovascular, hepatic, or
renal disease, unstable diabetes, symptomatic AIDS; not HIV-seropositivity alone).
2. Aspartate or alanine aminotransferase (AST, ALT) levels greater than three times the
upper limit of normal.
3. Individuals currently taking systemic anti-retroviral or anti-fungal therapy.
4. Current dependence (by DSM-IV criteria) on any psychoactive substance other than
opiates, caffeine, or nicotine.
5. Current, primary, Axis I psychiatric diagnosis other than opiate, caffeine, or
6. Females of childbearing potential who do not agree to use a medically acceptable
method of birth control. Acceptable methods include
1. oral contraceptive,
2. barrier (diaphragm or condom) - a spermicide is not required due to the
possibility of local irritation and allergic type reactions, but are recommended
3. levonorgestrel implant,
4. intrauterine progesterone contraceptive system,
5. medroxyprogesterone acetate contraceptive injection, or
6. complete abstinence.
7. Enrollment in an opiate-substitution (i.e., methadone, levo-alpha-acetylmethadol)
treatment program within 45 days of enrolling in the present study.
8. Individuals having taken (licitly or illicitly) LAAM, methadone, or naltrexone within
days of enrolling in the present study.
9. Individuals having taken buprenorphine, other than as an analgesic, within 365 days
of enrolling in the present study.
10. Participation in an investigational drug or device study within 45 days of enrolling
in the present study.
11. Anyone, who in the opinion of site principal investigator, would not be expected to
complete the first phase of the study protocol (e.g., due to pending incarceration or
probable relocation from the clinic area).