This project is part of a program project directed toward assessing cardiac effects of
particulate and other ambient air pollutants. In this project active elderly adults living
in the communities of Boston and Steubenville have attended 12 weekly sessions including
approximately 40 minutes of Holter monitoring, blood pressure, and oximetry evaluation
before, during, and after outdoor exercise. To investigate the relation of air pollution to
cardiac and pulmonary rehabilitation, a second portion of this study involves abstraction of
blood pressure and symptom data and downloading of available repeated measures telemetry
data in two populations. These populations include: 1) 200 outpatients attending 8 to 36
repeated weekly exercise training sessions in a major hospital cardiac rehabilitation unit.
Approximately 60 subjects have participated fully in Boston and Steubenville in the repeated
40 minute measurement of continuous EKG (Holter), blood pressure, and oximetry. In
Steubenville we have also measured exhaled nitrogen oxide, an index of pulmonary
inflammation. The exposure monitoring has included outdoor particle mass of PM2.5, outdoor
gaseous pollutants, and indoor home and personal monitoring to evaluate the indoor
contribution of pollution to health effects.
Participants are 50 to 90 years of age, but almost all are 60 and older. They have been
enrolled as volunteers from communities in Mission Park, Boston, and Steubenville.
Inclusion criteria includes the ability to walk on level ground. Exclusion criteria
includes unstable anginal, and baseline EKG patterns such as left bundle branch block that
would make difficult the detection of repolarization abnormalities. Participants live at
or near the study center which was located in an office or apartment in the apartment
building of the majority of the participants.