This study will investigate cerebral (brain) aneurysms and their possible inheritance
patterns in families. It will try to determine how often brain aneurysms occur in families
in which more than one member has had an aneurysm and to find the gene or genes that
contribute to their development.
People in families in which more than one family member had a cerebral aneurysm are eligible
for this 1-day study. They will undergo the following procedures:
- Blood will be drawn (no more than 3 to 4 tablespoons) for research to identify genes
that contribute to the development of brain aneurysms.
- A magnetic resonance angiograph (MRA) scan will be done to examine a specific brain
area where aneurysms typically occur. Magnetic resonance imaging uses a strong
magnetic field and radio waves to produce images of the brain and detect abnormalities.
If a more detailed picture of the brain is needed than can be obtained with MRA, a more
specific MRA scan will be done using a contrast dye to enhance the images.
Patients may be invited to participate in related NIH research studies.
This study is designed to explore the genetics of familial cerebral aneurysms. Families in
which more than one person has had a known cerebral aneurysm will be studied. Family
histories will be obtained and participants identified who are willing to come to the NIH
Clinical Center for an MRAngiograph and venipuncture. DNA will be isolated and linkage
studies undertaken to identify loci involved in the etiology of familial cerebral aneurysms,
using standard linkage approaches.
Participants and their relatives that are affected or at a higher risk for cerebral
aneurysms will be enrolled in this protocol.
For the MR Angiograph portion of the study, any participant that is not able to sign the
Clinical Center consent form due to metal implants, pregnancy, claustrophobia, or an
allergy to gadolinium as a contrast will be excluded from the imaging part of the study.