We are investigating the role of an enzyme (NQO1) in protection against the bone marrow
toxicity of the occupational and environmental toxicant benzene. All of the proposed studies
involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated
protection. Cells are obtained from healthy volunteers and protocols have undergone IRB
review and approval.
Healthy adult volunteers with blood counts in normal ranges and without evidence of
hepatitis or HIV infection.