Expired Study
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Seattle, Washington 98109


Purpose:

RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment. PURPOSE: This clinical trial studies lung function in pediatric patients who have undergone bone marrow transplant.


Study summary:

OBJECTIVES: - Determine the delayed effects of bone marrow transplantation preparative regimens on pulmonary function in children surviving at least 5 years after transplantation for hematologic malignancy. - Determine the relationship between pulmonary function and growth rates in these patients. - Determine the effect of growth hormone treatment on pulmonary function in these patients. - Determine the relationship between pulmonary function and age at time of transplantation in these patients. - Determine the incidence and severity of restrictive pulmonary disease, and whether these factors vary with increasing time after transplantation in these patients. OUTLINE: Patients undergo respiratory history, signs and symptoms assessment, pulmonary function tests (PFT) including spirometry, lung volumes, and diffusion, oxygen saturation by pulse oximetry, and height measurement. Patients are assessed at 5-10 years, 10-15 years, and over 15 years after bone marrow transplantation. Patients with abnormal PFTs are assessed at more frequent intervals as clinically indicated. PROJECTED ACCRUAL: Approximately 280 patients will be accrued for this study.


Criteria:

DISEASE CHARACTERISTICS: - Patients who have undergone bone marrow transplantation for hematologic malignancy at least 5 years ago - Disease-free survivors at least 6 years of age AND - Under 18 years of age at time of transplantation - Received prior allogeneic, unrelated donor, syngeneic, or autologous bone marrow transplantation - Able to perform pulmonary function tests PATIENT CHARACTERISTICS: Age: - See Disease Characteristics Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - See Disease Characteristics Chemotherapy: - Not specified Endocrine therapy: - Not specified Radiotherapy: - Not specified Surgery: - Not specified Other: - Any prior preparative regimen allowed


NCT ID:

NCT00009711


Primary Contact:

Study Chair
Jean E. Sanders, MD
Fred Hutchinson Cancer Research Center


Backup Contact:

N/A


Location Contact:

Seattle, Washington 98109
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 25, 2017

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