This trial tests the effectiveness of the drug amitriptyline vs placebo to relieve chronic
pain in adults that have had a spinal cord injury.
This double masked placebo-controlled trial will randomize patients (n=100) with a greater
than 6 month history spinal cord injury and a greater than 3 month history of associated
pain to a daily dose of amitriptyline or placebo for 6 weeks. Patients will be examined
before randomization by a study physician or nurse masked to their treatment assignment.
They will be assessed by telephone interview before, during treatment, at the end of
treatment and 4 months later to assess pain, pain interference with activities, physical
and mental health, and number of health care visits for pain.
- Spinal Cord Injury six months ago or longer
- Pain for 3 months or longer
- History of cardiovascular disease, seizures, or glaucoma
- Currently taking antidepressant medications
- Currently hyperthyroid or taking thyroid medicine
- Currently pregnant