This 5-week study will examine the effects of naltrexone on alcohol craving, drinking rates,
and reaction to drinking-related triggers, or cues, in participants' everyday environment
and in laboratory sessions. Participants will monitor and record their daily desires to
drink, environmental circumstances in which urges occur, and drinking behavior using a palm
top computer. Participants will receive naltrexone or a placebo. One week after receiving
medication, all participants will be asked to respond to alcohol-related cues that may or
may not arouse the desire to drink.
- Drink at least 4 days per week with 2 heavy drinking days (more than 6 standard
drinks for men, more than 5 drinks for women) per week on average during the month
prior to the study.
- Current interest in treatment or a history of treatment for alcohol problems.
- History of liver disease or current liver function tests greater than five times
- Opiate abuse or dependence, any opiate use two weeks before the study or a urine test
screen that is positive for opiates.
- Females, who are pregnant, nursing, or not using reliable birth control method.
- Daily use of acetaminophen.
- Living with someone who participated in this study.