RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining chemotherapy with peripheral stem cell
transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill
more tumor cells.
PURPOSE: This phase I/II trial is studying the side effects and best dose of temozolomide
when given with peripheral stem cell transplantation and to see how well they work in
treating children with newly diagnosed malignant glioma or recurrent CNS tumors or other
- Determine the maximum tolerated dose of temozolomide in children with newly diagnosed
malignant glioma or recurrent CNS or other solid tumors.
- Evaluate the toxicity of this treatment in these patients.
- Determine the activity of this treatment in these patients.
OUTLINE: This is a dose escalation study of temozolomide.
Patients receive filgrastim (G-CSF) subcutaneously (SQ) or IV beginning on day -5 and
continuing through at least day 3. Peripheral blood stem cells (PBSC) are collected on days
0, 2, and 4. Patients then receive oral temozolomide daily for 5 consecutive days. PBSC
collections are reinfused 1 day after the last dose of temozolomide. Patients also receive
G-CSF beginning at the time of transplant and continuing until blood counts recover.
Treatment continues in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of temozolomide until the maximum tolerated
dose (MTD) is determined. The MTD is defined as the dose at which 2 of 6 patients experience
dose limiting toxicities.
Patients are followed every 3 months for 1-3 years, then annually thereafter.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study over 12 months.
- Histologically confirmed newly diagnosed malignant glioma or recurrent malignant CNS
tumor of any pathology OR
- Histologically confirmed non-CNS tumor
- Recurrent soft tissue sarcomas (e.g., rhabdomyosarcoma)
- Recurrent or resistant neuroblastoma
- Recurrent Wilm's tumor
- Recurrent Ewing's sarcoma
- Recurrent primitive neuroectodermal tumors
- Recurrent nasopharyngeal carcinoma
- Recurrent germ cell tumor
- Expected cure rate less than 10% with standard therapy
- Measurable and/or active disease
- History of bone marrow tumor infiltration with or without mass lesions or isolated
abnormal CSF cytology as only evidence of recurrent disease allowed if complete
response was first achieved with primary conventional therapy
- 18 and under
- Karnofsky 70-100% OR
- Lansky 70-100%
- Greater than 8 weeks
- Reasonably cellular bone marrow (greater than 15% cellularity on biopsy)
- Absolute neutrophil count greater than 1,000/mm^3
- Platelet count greater than 75,000/mm^3
- Bilirubin less than 2.0 mg/dL
- SGPT less than 120 U/L
- Creatinine less than 1.5 mg/dL
- Systolic fraction or ejection fraction at least 80% predicted for age by
- CVC or DLCO at least 60% predicted for age OR clearance from pulmonologist
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- HIV negative
- No active infection
- Able to tolerate vigorous hydration schedule
PRIOR CONCURRENT THERAPY:
- No concurrent white blood cell transfusion
- No other concurrent hematopoietic growth factors
- See Disease Characteristics
- At least 4 weeks since prior chemotherapy
- No other concurrent cytotoxic drugs (systemic or intrathecal)
- Concurrent corticosteroids allowed
- See Disease Characteristics
- At least 1 week since prior radiotherapy
- At least 1 week since prior surgery
- No other concurrent investigational agents