Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Philadelphia, Pennsylvania 19103


Purpose:

Phase I trial to study the effectiveness of combination chemotherapy plus radiation therapy in treating women who have stage III or stage IV endometrial cancer. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells.


Study summary:

OBJECTIVES: I. Determine the feasibility of doxorubicin and cisplatin followed by whole abdominal radiotherapy in patients with stage III or IV endometrial cancer. II. Determine the acute and chronic toxic effects, in particular, severe and life-threatening gastrointestinal, hepatic, and hematologic toxic effects, of this regimen in these patients. OUTLINE: This is a multicenter study. Patients receive doxorubicin IV and cisplatin IV on day 1. Treatment repeats every 3 weeks for 3 courses. Patients then undergo whole abdominal radiotherapy 5 days a week for 4-6 weeks. Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 21-53 patients will be accrued for this study within 3.5 years.


Criteria:

Inclusion Criteria: - Histologically confirmed endometrial cancer including 1 of the following subtypes: - Clear cell carcinoma - Serous papillary carcinoma - Endometrioid adenocarcinoma - Stage III or IV disease - Positive adnexa - Metastases to serosa, bowel mucosa, abdomen - Positive pelvic or paraaortic nodes - Positive pelvic washings or vaginal involvement within the radiation port - Tumor must be surgically reduced to 2 cm or less within 8 weeks of study entry - Must have had a hysterectomy and bilateral salpingo oophorectomy - No recurrent disease - No distant metastases outside of abdominopelvic area, including: - Parenchymal liver metastases - Lung metastases - Positive inguinal lymph nodes - Positive supraclavicular nodes - Pleural effusion with malignant cytology - Performance status - GOG 0-2 - Absolute neutrophil count at least 1,500/mm^3 - Platelet count at least 100,000/mm^3 - Bilirubin no greater than 1.5 times upper limit of normal (ULN) - SGOT and alkaline phosphatase no greater than 3 times ULN - Creatinine no greater than ULN - Cardiac ejection fraction greater than 50% - No other prior or concurrent malignancy within the past 5 years except nonmelanoma skin cancer - No prior chemotherapy - No prior pelvic or abdominal radiotherapy - No prior radiotherapy for other prior malignancy


NCT ID:

NCT00005830


Primary Contact:

Principal Investigator
Jeffrey Fowler
Gynecologic Oncology Group


Backup Contact:

N/A


Location Contact:

Philadelphia, Pennsylvania 19103
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 24, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.