Expired Study
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Burlington, Vermont 05401


Purpose:

This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.


Criteria:

Inclusion Criteria: - normal weight-for-height weight 50-80 kg - normal physical activity - no significant medical history - healthy by medical exam and lab blood testing Exclusion Criteria: - subjects who exercise vigorously - subjects who smoke


NCT ID:

NCT00005767


Primary Contact:

Dwight Matthews, Ph.D.
Phone: 1-802-646-8114


Backup Contact:

N/A


Location Contact:

Burlington, Vermont 05401
United States

Dwight Matthews, Ph.D.
Phone: 802-646-8114

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: September 21, 2017

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