This study will examine the health-related quality of life in patients being treated for
chronic heart disease.
Patients 18 years or older with chronic ischemic heart disease and left ventricular
dysfunction enrolled in protocols in the National Heart Lung and Blood Institute's
Cardiology Branch may participate in this study.
Participants will complete five questionnaires at 3 separate times during the study-once
during hospitalization at the NIH Clinical Center and again at home 6 months and 1 year
later. The questionnaires, described below, require a total of about 30 minutes to
1. Demographic Information Sheet -General information such as age, marital status,
employment, education, and history of cardiac medical procedures.
2. General Health Survey -Patient's self-assessment, on a rating scale, of physical and
emotional well being. Questions are related to the ability to perform work and daily
living activities, mood and state of mind, limitations on social activities, energy
level, pain level, general quality of life, etc.
3. Heart Disease Survey - Patient's self-assessment, on a rating scale, of the level of
physical, social, emotional and functional well being related to his or her heart
condition. Questions concern fatigue level, emotional outlook, social well being, etc.
4. Angina Survey - Information on the frequency of chest pain, chest tightness, or angina.
5. Symptom Distress Survey - Patient's ranking of the degree of symptom distress from
chest discomfort, difficulty breathing, heart rate irregularities, wheezing and
All information provided in the questionnaires will be kept confidential. Upon request,
patients will be sent a summary of the study results when the study is completed.
A majority of the research in patients with chronic ischemic heart disease and left
ventricular dysfunction deals with increasing patient survival rates and years. Very little
research has focused on patients' perceptions of living with this chronic debilitating
disease. The purpose of this naturalistic, prospective study is to assess the Health
Related Quality of Life (HRQOL), anginal symptoms and symptom distress experienced by
patients with chronic ischemic heart disease and left ventricular dysfunction. The
relationship between underlying cardiac condition, anginal symptoms, symptom distress and
HRQOL will be examined. The trend in HRQOL across time versus treatment group will be
evaluated. The question, does HRQOL, anginal frequency and symptom distress at baseline
predict mortality and cardiac related hospitalization during the year following assessment
will also be addressed.
Patients who are enrolled in protocols in the Cardiology Branch of the National Heart Lung
and Blood Institute (NHLBI) and diagnosed with chronic ischemic heart disease and left
ventricular dysfunction will be asked to participate in this HRQOL study. Patients will
complete measures of HRQOL (Medical Outcomes Short Form 36 Survey; Minnesota Living with
Heart Failure Questionnaire) and symptom measures (anginal frequency subscale of the Seattle
Angina Questionnaire; cardiopulmonary subscale of the Heart Transplant Symptom Checklist).
Underlying cardiac condition will be assessed using exercise thallium imaging parameters
(METS and perfusion defects) and positron emission tomography (PET) imaging parameter
(viability). A sample size of 90 subjects is desired for this study. Data will be analyzed
using multivariate statistics. It is expected that this study will provide new information
regarding how patients with ischemic heart disease and left ventricular function feel their
chronic illness and its corresponding treatment(s) affects their HRQOL.
Known coronary artery disease.
Left ventricular ejection fraction less that or equal to 45%.
Signed informed consent.
Must be able to read written English.