Expired Study
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Philadelphia, Pennsylvania 19104


Purpose:

OBJECTIVES: I. Determine the pattern of immunologic reconstitution in patients with T-cell compromise due to DiGeorge syndrome or velocardiofacial syndrome. II. Determine any correlation between immunologic function in these patients and chromosome 22 deletion breakpoints. III. Determine presence of sustained immunologic compromise in older patients.


Study summary:

PROTOCOL OUTLINE: Blood samples are collected at diagnosis of chromosome 22q11 deletion and assessed for lymphocyte proliferation in response to mitogens phytohemagglutinin, pokeweed mitogen, and concanavalin A (mitogen stimulation analyses). These analyses are repeated at 4 months along with a quantitative analysis of immunoglobulin. At 8 months, patients are tested for their lymphocytes' ability to respond to antigens (candida, tetanus, and diphtheria). At 1 year, patients have lymphocyte subset, IgG, IgA, and IgM analyses performed. Quantitative evaluations of antibody titers to diphtheria, tetanus, Haemophilus influenza, and hepatitis B are also performed. Over 1 year of age, all studies are performed if the patient is seen for a single visit.


Criteria:

- Conotruncal cardiac lesion to be repaired by surgery AND Chromosome 22q11 deletion by FISH


NCT ID:

NCT00005102


Primary Contact:

Study Chair
Kathleen E. Sullivan
Children's Hospital of Philadelphia


Backup Contact:

N/A


Location Contact:

Philadelphia, Pennsylvania 19104
United States

Kathleen E. Sullivan
Phone: 215-590-1697

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: September 19, 2017

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