Expired Study
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New Haven, Connecticut 06520


Purpose:

OBJECTIVES: I. Determine the effect of repetitive transcranial magnetic stimulation on treatment refractory auditory hallucinations of patients with schizophrenia.


Study summary:

PROTOCOL OUTLINE: This is a randomized, double blind study. Patients are randomized to one of two treatment arms. Group I: Patients receive 9 sessions of active transcranial magnetic stimulation (rTMS) which consists of 8 minutes of rTMS during session 1, 12 minutes duration during session 2, and 16 minutes duration during sessions 3-9. The total duration of stimulation is 132 minutes. Each session was given on a separate day and in general each session occurred on consecutive days with the exception of weekends. Group II: Patients receive 9 sessions of sham stimulation, which consists of 8 minutes of sham stimulation during session 1, 12 minutes duration sham stimulation during session 2, and 16 minutes duration sham stimulation during sessions 3-9. The total duration of sham stimulation is 132 minutes. Each session was given conducted on a separate day and in general each session occured on consecutive days with the exception of weekends. This study provided pilot data supplying the basis for our current study - NCT00308997 -- see our website for details


Criteria:

PROTOCOL ENTRY CRITERIA: Inclusion criteria: - Diagnosis of schizophrenia or schizoaffective disorder based on DSM-IV version of SCID - Auditory hallucinations of spoken speech occurring at least 5 times per day where subject able to discern verbal content - Right-handed - At least 4 weeks on stable antipsychotic medication Exclusion criteria: - history of seizure (unless due to drug withdrawal or medication that is no longer prescribed) - history of epilepsy in first degree relatives - estimated IQ less than 80 - unable to provide informed consent - significant unstable medical condition - current treatment with clozapine or bupropion - cochlear implants or other metal in the head (surgical, etc.) - history of cardiac arrhythmia - cardiac pacemaker - active drug or alcohol abuse within prior 6 weeks - pregnancy


NCT ID:

NCT00004980


Primary Contact:

Study Chair
Ralph Hoffman
Yale University


Backup Contact:

N/A


Location Contact:

New Haven, Connecticut 06520
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 24, 2017

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