The purpose of this study is to better understand the long-term progress of people with
obsessive-compulsive disorder (OCD) and related conditions such as anorexia nervosa,
Tourette syndrome, and trichotillomania.
This study involves the screening and follow-up of individuals with OCD and OCD-related
disorders. Participants will be screened with a medical and psychiatric evaluation,
questionnaires, and neurological testing. Participants will then have study visits every 4
to 12 weeks to undergo symptom and daily functioning evaluations, personality tests, blood
and urine tests, memory tests, brain scans, and other clinical exams. Participants will be
assessed with interviews and paper-and-pencil or computer-assisted tests. Participants may
have the opportunity to participate in drug studies and to join a monthly OCD support group.
At the end of the study, participants will be referred to community or private treatment
The purpose of this protocol is to allow for careful screening and follow-up of patients
with obsessive-compulsive disorder (OCD) and OCD-related disorders for a variety of
protocols, recording demographic and rating information over the long-term course of the OCD
illness and associated anxiety and depression symptoms. Patients in this study will be asked
to participate in the naturalistic baseline assessment phase to better understand the
pathophysiology and long-term course of illness. As a part of this protocol, subjects will
be systematically administered assessment measures including diagnostic and psychological
screening tests, a psychiatric assessment, SCID I and SCID II interviews, as well as other
rating scales. They will also be informed of their opportunity to participate in research
procedures such as blood draws and MRI of the brain. Upon conclusion of their participation,
they will be referred out to community/private treatment when appropriate. All will be
offered participation in an ongoing support group. This protocol will serve as an entry
point for individuals with OCD and OCD-related disorders to proceed into other investigation
- INCLUSION CRITERIA:
Individuals must fulfill DSM IV criteria for OCD or OCD-related disorders as determined by
a complete psychiatric diagnostic interview (SCID-I, using DSM IV-TR).
Individuals must be capable of decision making, and able to comprehend the purpose of the
study and to provide informed consent.
Individuals can be included if they have certain medical conditions that have been
described to have a higher incidence of OCD/depression and anxiety disorders: e.g.,
individuals with underlying neurological or neuropsychiatric conditions (e.g., tic
disorders or dystonias, including torticollis and blepharospasm), connective tissue
disorders, but must show no other serious or acute medical illnesses as determined by a
physical exam and standard laboratory examinations.
Individuals must be at least 18 years old.
Alcohol or substance use or dependence of sufficient magnitude to require independent,
concurrent treatment intervention (e.g., antabuse or opiate treatment, but not including
Current history of aggressive behavior or current suicidal ideation with plan and intent.
Current active psychosis.