Expired Study
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Portland, Oregon 97239


Purpose:

OBJECTIVES: I. Assess the biosynthesis of cholesterol and cholestanol, and measure the turnover of individual sterols and bile acids in patients with cerebrotendinous xanthomatosis before and after a cholesterol- and cholestanol-free diet. II. Assess the biosynthesis of cholesterol and cholestanol, and measure the turnover of individual sterols and bile acids in these patients before and after lovastatin and chenodeoxycholic acid.


Study summary:

PROTOCOL OUTLINE: Following a 2-week baseline assessment, patients participate in a feeding study for up to 3 weeks. The diet is free of cholesterol and cholestanol. For the next 4 weeks, patients return to their typical diet and are medicated with daily lovastatin and chenodeoxycholic acid. The feeding study is repeated for an additional 3 weeks, with the patient taking either lovastatin or chenodeoxycholic acid.


Criteria:

PROTOCOL ENTRY CRITERIA: Cerebrotendinous xanthomatosis


NCT ID:

NCT00004346


Primary Contact:

Study Chair
William Connor
Oregon Health and Science University


Backup Contact:

N/A


Location Contact:

Portland, Oregon 97239
United States

Sonja Connor
Phone: 503-494-7775
Email: connors@ohsu.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: September 20, 2017

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