OBJECTIVES: I. Investigate the pathobiology of Tourette syndrome and related disorders by
measuring various compounds of interest in cerebrospinal fluid, plasma, and urine of
patients with Tourette syndrome, obsessive compulsive disorder, and/or chronic tics.
II. Determine the pattern of familial aggregation of Tourette syndrome and obsessive
compulsive disorder by systematic assessment of all first-degree family members of patients
selected for cerebrospinal fluid studies.
III. Establish the neurochemical and neuropeptide profile associated with the range of
expression of the putative Tourette gene expression in adult and adolescent patients.
PROTOCOL OUTLINE: All patients are screened with a complete physical and neurologic exam,
and a semi-structured interview. Patients then receive a comprehensive assessment of
systemic disease. Patients and first-degree family members also participate in a genetic
Any patient who experiences an unusual exacerbation of symptoms or significant side effects
is removed from the study.
PROTOCOL ENTRY CRITERIA:
Diagnostic and Statistical Manual of Mental Disorders IV lifetime diagnosis of 1 or more
of the following:
- Tourette syndrome (TS)
- Obsessive compulsive disorder
- Chronic tics
Severely affected adolescents with a score of 3 or greater on the TS-Clinical Global
Impression Scale eligible
At least 1 month since any medication
- In good physical health
- No alcohol or substance abuse
- No Intelligence Quotient below 80
- Negative pregnancy test required of fertile women